2023
Leung J, Strong C, Badior KE, Robertson M, Wu X, Meledeo MA, Kang E, Paul M, Sato Y, Harashima H, Cap AP, Devine DV, Jan E, Cullis PR, Kastrup CJ. 2023. Genetically engineered transfusable platelets using mRNA lipid nanoparticles. Sci Adv. 2023 Dec;9(48):eadi0508. doi: 10.1126/sciadv.adi0508. Epub 2023 Dec 1.
Bolsoni J, Liu D, Mohabatpour F, Ebner R, Sadhnani G, Tafech B, Leung J, Shanta S, An K, Morin T, Chen Y, Arguello A, Choate K, Jan E, Ross CJD, Brambilla D, Witzigmann D, Kulkarni J, Cullis PR, Hedtrich S. 2023. Lipid Nanoparticle-Mediated Hit-and-Run Approaches Yield Efficient and Safe In Situ Gene Editing in Human Skin. ACS Nano. 2023 Nov 2. doi: 10.1021/acsnano.3c08644. Online ahead of print.
Cleavage of 14-3-3ε by the enteroviral 3C protease dampens RIG-I mediated antiviral signaling. Andrews DDT, Vlok M, Akbari Bani D, Hay BN, Mohamud Y, Foster LJ, Luo H, Overall CM, Jan E. 2023. J Virol. 2023 Aug 31;97(8):e0060423. doi.org/10.1128/jvi.00604-23
Induction of Bleb Structures in Lipid Nanoparticle Formulations of mRNA Leads to Improved Transfection Potency.
An insect viral protein disrupts stress granule formation in mammalian cells. Sadasivan J, Hyrina A, Dasilva R, Jan E. 2023. J Mol Biol. 2023 Mar 8:168042. doi: 10.1016/j.jmb.2023.168042. Online ahead of print.
Antibacterial and Antiviral Coating on Surfaces through Dopamine Based Co-deposition of Antifouling Polymer and Nanosilver. Yu K, Warsaba R, Yazdani-Ahmadabadi H, Lange D, Jan E, Kizhakkedathu J. 2023. ACS Biomater Sci Eng. 2023 Jan 9;9(1):329-339. doi: 10.1021/acsbiomaterials.2c01350. Epub 2022 Dec 14.
2022
Targeting Nup358/RanBP2 by a viral protein disrupts stress granule formation. Sadasivan J, Vlok M, Wang X, Nayak A, Andino R, Jan E. 2022. PloS Pathogens 18(12): e1010598. doi.org/10.1371/journal.ppat.1010598
Expansion of viral genomes with viral protein genome linked copies. Warsaba R, Salcedo-Porras N, Flibotte S, Jan E. 2022. Virology. 2022 Nov 11;577:174-184. doi: 10.1016/j.virol.2022.10.012.
Filamin A regulates caspase-3 cleavage in platelets in a protein kinase C (PKC)-dependent manner. De Silva E, Devine D, Jan E, Roskelley C, Kim H. Biochem J. 2022 Oct 14:BCJ20220177. doi: 10.1042/BCJ20220177. Epub ahead of print. PMID: 36239738.
Multiple viral protein genome-linked proteins compensate viral translation in +ssRNA virus infection. Warsaba R, Stoynov N, Moon KM, Flibotte S, Foster LJ, Jan E. J Virol. 2022 Aug 22:e0069922. doi: 10.1128/jvi.00699-22 Online ahead of print.
The hinge region of the Israeli acute paralysis virus internal ribosome entry site directs ribosomal positioning, translational activity and virus infection. Kirby MP, Stevenson C, Worrall LJ, Chen Y, Young C, Youm J, Strynadka NCJ, Allan DW, Jan E. J Virol. 2022 Mar 9;96(5):e0133021. doi: 10.1128/JVI.01330-21. Epub 2022 Jan 12. doi.org/10.1128/JVI.01330-21
2021
Resurrection of a viral internal ribosome entry site from a 700 year old ancient Northwest Territories cripavirus. Wang X, Vlok M, Flibotte S, and Jan E. Viruses. 2021 Mar 17;13(3):493. doi: 10.3390/v13030493
Eukaryotic translation initiation factor 2A protects pancreatic beta cells during endoplasmic reticulum stress while rescuing translation inhibition. Panzhinskiy E, Skovsø S, Cen HH, Chu KY, MacDonald K, Soukhatcheva G, Dionne DA, Hallmaier-Wacker LK, Wildi JS, Marcil S, Noursadeghi N, Taghizadeh F, Verchere CB, Jan E, Johnson JD. Under Revision
2020
The papain-like protease of coronaviruses cleaves ULK1 to disrupt host autophagy. Biochem Biophys Res Commun. 2021 Jan 8;540:75-82. doi: 10.1016/j.bbrc.2020.12.091. Online ahead of print.
New features on the genomic organization of a novel dicistrovirus identified from the sweet potato whitefly Bemisia tabaci. Hedil M, Nakasu EYT, Nagata T, Wen J, Jan E, Michereff-Filho M, Inoue-Nagata AK. Virus Res. 2020 Oct 15;288:198112. doi: 10.1016/j.virusres.2020.198112. Epub 2020 Aug 7.
Dynamic rewiring of the human interactome by interferon signaling. Kerr CH, Skinnider MA, Andrews DDT, Madero AM, Chan QWT, Stacey RG, Stoynov N, Jan E, Foster LJ. Genome Biol. 2020 Jun 15;21(1):140. doi: 10.1186/s13059-020-02050-y.
2019
Cleavage and Sub-Cellular Redistribution of Nuclear Pore Protein 98 by Coxsackievirus B3 Protease 2A Impairs Cardioprotection. Hanson PJ, Hossain AR, Qiu Y, Zhang HM, Zhao G, Li C, Lin V, Sulaimon S, Vlok M, Fung G, Chen VH, Jan E, McManus BM, Granville DJ, Yang D. Front Cell Infect Microbiol. 2019 Jul 24;9:265. doi: 10.3389/fcimb.2019.00265. eCollection 2019.
Dicistrovirus-Host Molecular Interactions Warsaba R, Sadasivan J, Jan E. Curr Issues Mol Biol. 2019 Jun 6;34:83-112. doi: 10.21775/cimb.034.083.
NLRP3 deficiency exacerbates enterovirus infection in mice. Wang C, Fung G, Deng H, Jagdeo J, Mohamud Y, Xue YC, Jan E, Hirota JA, Luo H. FASEB J.2019 Jan;33(1):942-952. doi: 10.1096/fj.201800301RRR. Epub 2018 Aug 6.
2018
Transmission of Cricket paralysis virus via exosome-like vesicles during infection of Drosophila cells. Kerr CH, Dalwadi U, Scott NE, Yip CK, Foster LJ, Jan E. Sci Rep. 2018 Nov 26;8(1):17353. doi: 10.1038/s41598-018-35717-5.
IRES-mediated ribosome repositioning directs translation of a +1 overlapping ORF that promotes virus infection. Kerr CH#, Wang QS#, Moon KM, Keatings K, Allan DW, Foster LJ, Jan E. 2018. Nucleic Acids Res. 2018 Nov 10. doi: 10.1093/nar/gky1121. [Epub ahead of print] # contributed equally
Cellular metabolism constrains innate immune responses in early human ontogeny. Kan B, Michalski C, Fu H, Au HHT, Lee K, Marchant EA, Cheng MF, Anderson-Baucum E, Aharoni-Simon M, Tilley P, Mirmira RG, Ross CJ, Luciani DS, Jan E, Lavoie PM. Nat Commun. 2018 Nov 16;9(1):4822. doi: 10.1038/s41467-018-07215-9.
A viral Argonaute suppressor implements a dual program to restrict antiviral immunity. Nayak A, Kim DY, Trnka MJ, Kerr CH, Stanley D, Rivera BM, Li K, Burlingame AL, Jan E, Frydman J, Gross J, Andino R. Cell Host Microbe. 2018 Oct 10;24(4):542-557.e9. doi: 10.1016/j.chom.2018.09.006
N-terminomics TAILS identifies host cell substrates of poliovirus and coxsackievirus B3 3C proteinases that modulate virus infection. Jagdeo JM, Dufour A, Klein T, Solis N, Kleifeld O, Kizhakkedathu J, Luo H, Overall CM and Jan E. J Virol. 2018 Mar 28;92(8). pii: e02211-17. doi: 10.1128/JVI.02211-17.
Functional insights into the adjacent stem-loop in honey bee dicistroviruses that promotes IRES-mediated translation and viral infection. Au HHT, Elspass VM, Jan E. J Virol. 2018 Jan 2;92(2). pii: e01725-17. doi: 10.1128/JVI.01725-17.
2017
Disruption of stress granule formation by the multifunctional cricket paralysis virus 1A protein. Khong A, Kerr CH, Yeung CH, Keatings K, Nayak A, Allan DW, Jan E. J Virol. 2017 Feb 14;91(5). pii: e01779-16. doi: 10.1128/JVI.01779-16. Print 2017 Mar 1.
2016
Molecular analysis of the factorless internal ribosome entry site in Cricket Paralysis virus infection Kerr CH, Ma ZW, Jang CJ, Thompson SR, Jan E. Sci Rep. 2016 Nov 17;6:37319. doi: 10.1038/srep37319.
tRNA-mimicry in IRES-mediated translation and recoding. Butcher SE, Jan E. RNA Biol. 2016 Nov;13(11):1068-1074.
A Cap-to-Tail Guide to mRNA Translation Strategies in Virus-Infected Cells. Jan E, Mohr I, Walsh D. Annu Rev Virol. 2016 Aug 3.
Temporal regulation of distinct internal ribosome entry sties of the dicistrovirus cricket paralysis virus Khong A, Bonderoff JM, Spriggs RV, Tammpere E, Kerr CH, Jackson TJ, Willis AE, Jan E. Viruses. 2016 Jan 19;8(1). pii: E25.
Commandeering the ribosome: lessons learned from Dicistroviruses about translation. Kerr CH, Jan E. J Virol. 2016 Apr 6. pii: JVI.00737-15. [Epub ahead of print]
2015
Global shape mimicry of tRNA within a viral internal ribosome entry site mediates translational reading frame selection. Au HH, Cornilescu G, Mousakis KD, Ren Q, Burke JE, Lee S, Butcher SE, Jan E. Proc. Natl. Acad. Sci. USA. 2015 Nov 24;112(47):E6446-55. doi: 10.1073/pnas.1512088112. Epub 2015 Nov 9.
Editorial overview: Virus structure and expression. Jan E, Tao YJ. Curr Opin Virol. 2015 Jun;12:ix-x. doi: 10.1016/j.coviro.2015.05.005. Epub 2015 Jun 6.
Heterogeneous nuclear ribonucleoprotein M facilitates enterovirus infection. Jagdeo JM, Dufour A, Fung G, Luo H, Overall CM, Jan E. J Virol. 2015 Jul;89(14):7064-78.
The 5′ untranslated region of a novel infectious molecular clone of the dicistrovirus cricket paralysis virus modulates infection. Kerr CH, Wang QS, Keatings K, Khong A, Allan D, Yip CK, Foster LJ, Jan E. J Virol. 2015 Jun;89(11):5919-34. doi: 10.1128/JVI.00463-15. Epub 2015 Mar 25.
Molecular biology: signals across domains of life. Jan E. Nature. 2015 Mar 5;519(7541):40-1. doi: 10.1038/nature14202. Epub 2015 Feb 4. No abstract available.
Stress-mediated translational control in cancer cells. Leprivier G, Rotblat B, Khan D, Jan E, Sorensen PH. Biochim Biophys Acta. 2015 Jul;1849(7):845-60. doi: 10.1016/j.bbagrm.2014.11.002. Epub 2014 Nov 10. Review.
2014
Switch from cap- to factorless IRES-dependent 0 and +1 frame translation during cellular stress and dicistrovirus infection. Wang QS, Jan E. . PLoS One. 2014 Aug 4;9(8):e103601. doi: 10.1371/journal.pone.0103601. eCollection 2014.
Novel viral translation strategies. Au HH, Jan E. Wiley Interdiscip Rev RNA. 2014 Nov-Dec;5(6):779-801. doi: 10.1002/wrna.1246. Epub 2014 Jul 8. Review.
Structural determinants of an internal ribosome entry site that direct translational reading frame selection. Ren Q, Au HH, Wang QS, Lee S, Jan E. Nucleic Acids Res. 2014 Aug;42(14):9366-82. doi: 10.1093/nar/gku622. Epub 2014 Jul 18.
2013
Production of a dominant-negative fragment due to G3BP1 cleavage contributes to the disruption of mitochondria-associated protective stress granules during CVB3 infection. Fung G, Ng CS, Zhang J, Shi J, Wong J, Piesik P, Han L, Chu F, Jagdeo J, Jan E, Fujita T, Luo H. PLoS One. 2013 Nov 18;8(11):e79546. doi: 10.1371/journal.pone.0079546. eCollection 2013.
Severity of X-linked dyskeratosis congenita (DKCX) cellular defects is not directly related to dyskerin (DKC1) activity in ribosomal RNA biogenesis or mRNA translation. Thumati NR, Zeng XL, Au HH, Jang CJ, Jan E, Wong JM. Hum Mutat. 2013 Dec;34(12):1698-707. doi: 10.1002/humu.22447. Epub 2013 Oct 21.
On the off pill sildenafil chance that you are more likely to attract women’s attention. Patient without complications of high blood pressure are also unica-web.com purchase generic levitra medicated for the condition. This type of treatment sildenafil online pharmacy is often used for diabetes. In case of need mostly we use glucose to provide power and force https://www.unica-web.com/archive/2015/unica2015-candidates-jeanne-glass.html generic viagra of our muscles and other tissues to absorb glucose from the blood.
Cleavage of sequestosome 1/p62 by an enteroviral protease results in disrupted selective autophagy and impaired NFKB signaling. Shi J, Wong J, Piesik P, Fung G, Zhang J, Jagdeo J, Li X, Jan E, Luo H. Autophagy. 2013 Oct;9(10):1591-603. doi: 10.4161/auto.26059. Epub 2013 Aug 13.
The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation. Leprivier G, Remke M, Rotblat B, Dubuc A, Mateo AR, Kool M, Agnihotri S, El-Naggar A, Yu B, Somasekharan SP, Faubert B, Bridon G, Tognon CE, Mathers J, Thomas R, Li A, Barokas A, Kwok B, Bowden M, Smith S, Wu X, Korshunov A, Hielscher T, Northcott PA, Galpin JD, Ahern CA, Wang Y, McCabe MG, Collins VP, Jones RG, Pollak M, Delattre O, Gleave ME, Jan E, Pfister SM, Proud CG, Derry WB, Taylor MD, Sorensen PH. Cell. 2013 May 23;153(5):1064-79. doi: 10.1016/j.cell.2013.04.055.
Cytoplasmic redistribution and cleavage of AUF1 during coxsackievirus infection enhance the stability of its viral genome. Wong J, Si X, Angeles A, Zhang J, Shi J, Fung G, Jagdeo J, Wang T, Zhong Z, Jan E, Luo H. FASEB J. 2013 Jul;27(7):2777-87. doi: 10.1096/fj.12-226498. Epub 2013 Apr 9.
The small molecule genkwanine M induces single mode, mesenchymal tumor cell motility. Zimmerman C, Austin P, Khong A, McLeod S, Bean B, Forestieri R, Andersen RJ, Jan E, Roberge M, Roskelley CD. Exp Cell Res. 2013 Apr 1;319(6):908-17. doi: 10.1016/j.yexcr.2013.01.005. Epub 2013 Jan 17.
2012
Insights into factorless translational initiation by the tRNA-like pseudoknot domain of a viral IRES. Au HH, Jan E. PLoS One. 2012;7(12):e51477. doi: 10.1371/journal.pone.0051477. Epub 2012 Dec 7.
Methods for studying IRES-mediated translation of positive-strand RNA viruses. Wang QS, Au HH, Jan E. Methods. 2013 Feb;59(2):167-79. doi: 10.1016/j.ymeth.2012.09.004. Epub 2012 Sep 23. Review.
A daphnane diterpenoid isolated from Wikstroemia polyantha induces an inflammatory response and modulates miRNA activity. Khong A, Forestieri R, Williams DE, Patrick BO, Olmstead A, Svinti V, Schaeffer E, Jean F, Roberge M, Andersen RJ, Jan E. PLoS One. 2012;7(6):e39621. doi: 10.1371/journal.pone.0039621. Epub 2012 Jun 26.
Alternative reading frame selection mediated by a tRNA-like domain of an internal ribosome entry site. Ren Q, Wang QS, Firth AE, Chan MM, Gouw JW, Guarna MM, Foster LJ, Atkins JF, Jan E. Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):E630-9. doi: 10.1073/pnas.1111303109. Epub 2012 Jan 13.
2011
mTOR signaling regulates the processing of pre-rRNA in human cells. Iadevaia V, Zhang Z, Jan E, Proud CG. Nucleic Acids Res. 2012 Mar;40(6):2527-39. doi: 10.1093/nar/gkr1040. Epub 2011 Nov 24.
Translation-competent 48S complex formation on HCV IRES requires the RNA-binding protein NSAP1. Park SM, Paek KY, Hong KY, Jang CJ, Cho S, Park JH, Kim JH, Jan E, Jang SK. Nucleic Acids Res. 2011 Sep 1;39(17):7791-802. doi: 10.1093/nar/gkr509. Epub 2011 Jun 28.
Modulation of stress granules and P bodies during dicistrovirus infection. Khong A, Jan E. J Virol. 2011 Feb;85(4):1439-51. doi: 10.1128/JVI.02220-10. Epub 2010 Nov 24.
2010
Phosphatidic acid is a pH biosensor that links membrane biogenesis to metabolism. Young BP, Shin JJ, Orij R, Chao JT, Li SC, Guan XL, Khong A, Jan E, Wenk MR, Prinz WA, Smits GJ, Loewen CJ. Science. 2010 Aug 27;329(5995):1085-8. doi: 10.1126/science.1191026.
Modular domains of the Dicistroviridae intergenic internal ribosome entry site. Jang CJ, Jan E. RNA. 2010 Jun;16(6):1182-95. doi: 10.1261/rna.2044610. Epub 2010 Apr 27.
2009
Bioinformatic evidence for a stem-loop structure 5′-adjacent to the IGR-IRES and for an overlapping gene in the bee paralysis dicistroviruses. Firth AE, Wang QS, Jan E, Atkins JF. Virol J. 2009 Nov 6;6:193. doi: 10.1186/1743-422X-6-193.
Host and viral translational mechanisms during cricket paralysis virus infection. Garrey JL, Lee YY, Au HH, Bushell M, Jan E. J Virol. 2010 Jan;84(2):1124-38. doi: 10.1128/JVI.02006-09. Epub 2009 Nov 4.
The Imd pathway is involved in antiviral immune responses in Drosophila. Costa A, Jan E, Sarnow P, Schneider D. PLoS One. 2009 Oct 15;4(10):e7436. doi: 10.1371/journal.pone.0007436.
ABC50 promotes translation initiation in mammalian cells. Paytubi S, Wang X, Lam YW, Izquierdo L, Hunter MJ, Jan E, Hundal HS, Proud CG. J Biol Chem. 2009 Sep 4;284(36):24061-73. doi: 10.1074/jbc.M109.031625. Epub 2009 Jul 1.
LC3-mediated fibronectin mRNA translation induces fibrosarcoma growth by increasing connective tissue growth factor. Ying L, Lau A, Alvira CM, West R, Cann GM, Zhou B, Kinnear C, Jan E, Sarnow P, Van de Rijn M, Rabinovitch M. J Cell Sci. 2009 May 1;122(Pt 9):1441-51. doi: 10.1242/jcs.025957. Epub 2009 Apr 14.
Conserved element of the dicistrovirus IGR IRES that mimics an E-site tRNA/ribosome interaction mediates multiple functions. Jang CJ, Lo MC, Jan E. J Mol Biol. 2009 Mar 20;387(1):42-58. doi: 10.1016/j.jmb.2009.01.042. Epub 2009 Jan 29.
An upstream open reading frame regulates translation of GADD34 during cellular stresses that induce eIF2alpha phosphorylation. Lee YY, Cevallos RC, Jan E. J Biol Chem. 2009 Mar 13;284(11):6661-73. doi: 10.1074/jbc.M806735200. Epub 2009 Jan 8.
2006
Initiation factor-independent translation mediated by the hepatitis C virus internal ribosome entry site. Lancaster AM, Jan E, Sarnow P. RNA. 2006 May;12(5):894-902. Epub 2006 Mar 23.
2005
Divergent IRES elements in invertebrates. Jan E. Virus Res. 2006 Jul;119(1):16-28. Epub 2005 Nov 22. Review.
Biosynthetic labeling of RNA with uracil phosphoribosyltransferase allows cell-specific microarray analysis of mRNA synthesis and decay. Cleary MD, Meiering CD, Jan E, Guymon R, Boothroyd JC. Nat Biotechnol. 2005 Feb;23(2):232-7. Epub 2005 Jan 30.
2004
Cryo-EM visualization of a viral internal ribosome entry site bound to human ribosomes: the IRES functions as an RNA-based translation factor. Spahn CM, Jan E, Mulder A, Grassucci RA, Sarnow P, Frank J. Cell. 2004 Aug 20;118(4):465-75.
2003
Divergent tRNA-like element supports initiation, elongation, and termination of protein biosynthesis. Jan E, Kinzy TG, Sarnow P. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15410-5. Epub 2003 Dec 12.
2002
Factorless ribosome assembly on the internal ribosome entry site of cricket paralysis virus. Jan E, Sarnow P. J Mol Biol. 2002 Dec 13;324(5):889-902.
